3-(3-methyl-2-thienyl)acrylic acid

3-(3-methyl-2-thienyl)acrylic acid - Names and Identifiers

Name	(2E)-3-(3-methylthiophen-2-yl)prop-2-enoic acid
Synonyms	RARECHEM BK HD 0001 3-(3-methyl-2-thienyl)acrylic acid 3-(3-METHYL-2-THIENYL)ACRYLIC ACID (E)-3-(3-methyl-2-thienyl)acrylic acid 3-(3-Methyl-thiophen-2-yl)-acrylicacid 3-(3-METHYL-2-THIENYL)-2-PROPENOIC ACID (2E)-3-(3-Methyl-2-thienyl)acrylic acid (2E)-3-(3-methyl-2-thienyl)acrylic acid (2E)-3-(3-Methyl-2-thienyl)-2-propenoic acid (2E)-3-(3-methylthiophen-2-yl)prop-2-enoic acid 2-propenoic acid, 3-(3-methyl-2-thienyl)-, (2E)-
CAS	77741-66-3
InChI	InChI=1/C8H8O2S/c1-6-4-5-11-7(6)2-3-8(9)10/h2-5H,1H3,(H,9,10)/b3-2+

3-(3-methyl-2-thienyl)acrylic acid - Physico-chemical Properties

Molecular Formula	C8H8O2S
Molar Mass	168.21
Density	1.286g/cm³
Boling Point	302.9°C at 760 mmHg
Flash Point	137°C
Vapor Presure	0.000423mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.636

3-(3-methyl-2-thienyl)acrylic acid - Risk and Safety

Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves.
HS Code	29339900
Hazard Class	IRRITANT

3-(3-methyl-2-thienyl)acrylic acid - Introduction

(2E)-3-(3-methylthiophen-2-yl)prop-2-enoic acid is an organic compound with the chemical formula C10H9O2S. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: White crystalline solid
-Melting point: 65-67°C
-Boiling point: 358.5°C
-Solubility: Soluble in most organic solvents, such as ethanol and dimethylformamide

Use:
(2E)-3-(3-methylthiophen-2-yl)prop-2-enoic acid is commonly used in organic chemical synthesis and materials science research. It can be used as a monomer for polymerization reactions and for the preparation of polymers with special functions. In addition, it can also be used to prepare other organic compounds, such as drugs and ligands, and as a component in the synthesis of new materials.

Preparation Method:
There are two main methods for preparing (2E)-3-(3-methylthiophen-2-yl)prop-2-enoic acid:
1. synthetic method one: prepared by cyclic pyrimidine thiophene cyclization reaction. First, 3-methylthiopyridin-2-one is reacted with bromoacetate to prepare 3-(3-methyl-2-thienyl) acetone. Then, (2E)-3-(3-methylthiophen-2-yl)prop-2-enoic acid is obtained by acid-catalyzed hydrogenation.
2. synthetic method two: prepared by thiophene coupling reaction. First, 3-bromopropionic acid and ethyl thioacetate are reacted to produce ethyl 3-thiopropionate. This is then reacted with acetylene to produce 3-(3-aminobutyl) prop-2-ene-1-ammonium sulfate. Finally, (2E)-3-(3-methylthiophen-2-yl)prop-2-enoic acid is obtained by solid ammonolysis or acidolysis.

Safety Information:
(2E)-3-(3-methylthiophen-2-yl)prop-2-enoic acid is generally a safer chemical under normal conditions of use. However, caution is still needed to prevent danger. When handling the substance, appropriate laboratory safety measures should be observed, including wearing appropriate personal protective equipment, such as gloves and protective glasses, to avoid skin contact and inhalation. In addition, it should be stored in a dry, well-ventilated place, away from fire and oxidizing agents.

Last Update：2024-04-09 21:01:54